Detection of Xanthochromia in Cerebrospinal Fluid by Spectrophotometric Scan

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Detection of xanthochromia in cerebrospinal fluid.

Lumbar puncture (LP) still has an important role to play in the diagnosis of subarachnoid hemorrhage. Although computed tomography (CT) scanning has replaced LP as the investigation of first choice, within 24 h of ictus 5% of cases will show no evidence of hemorrhage on CT scanning; this percentage is as high as 50% by 1 week, 30% after 2 weeks, and 0% after 3 weeks (1). By definition, xanthoch...

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Unrecognized preanalytical problem with the spectrophotometric analysis of cerebrospinal fluid for xanthochromia.

1. Janssen AJM, Trijbels FJM, Sengers RCA, Smeitink JAM, van den Heuvel LP, Wintjes LTM, et al. Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin Chem 2007;53:729–34. 2. Bénit P, Slama A, Rustin P. Decylubiquinol impedes mitochondrial respiratory chain complex I activity. Mol Cell Biochem. 2008;314:45–50. 3. Esposti MD, Ngo A, Ghell...

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Why human color vision cannot reliably detect cerebrospinal fluid xanthochromia.

BACKGROUND Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds. METHODS Colorimetric and spectrophotometric analysis of CSF samples for recognizing the presence of bilirubin either in low concentrations or in the presence of hemolysed blood. RESULTS The experiment...

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ژورنال

عنوان ژورنال: American Journal of Clinical Pathology

سال: 2014

ISSN: 1943-7722,0002-9173

DOI: 10.1093/ajcp/142.suppl1.022